Parallel SCSI (formally, SCSI Parallel Interface, or SPI) is the earliest of the interface implementations in the SCSI family. SPI is a parallel bus; there is one set of electrical connections stretching from one end of the SCSI bus to the other. A SCSI device attaches to the bus but does not interrupt it. Both ends of the bus must be terminated.

SCSI is a peer-to-peer peripheral interface. Every device attaches to the SCSI bus in a similar manner. Depending on the version, up to 8 or 16 devices can be attached to a single bus. There can be multiple hosts and multiple peripheral devices but there should be at least one host. The SCSI protocol defines communication from host to host, host to a peripheral device, and peripheral device to a peripheral device. The Symbios Logic 53C810 chip is an example of a PCI host interface that can act as a SCSI target.

SCSI-1 and SCSI-2 have the option of parity bit error checking. Starting with SCSI-U160 (part of SCSI-3) all commands and data are error checked by a cyclic redundancy check.